HW and the elementary evolutionary operator

**lecture 1** (lecture1)

**simulation1** (lec11)

Evolutionary operator of the population.Two level populations.One-locus multiallele systems. Selection against recessive lethal gene and selection in case Thalassemia. General selection equations

**lecture 2** (lecture2)

**simulation1** (letal)

**simulation2** (talas)

*Equilibria points and trajectories.Mean fitness calculation and dynamics.*

**lecture 3** (lecture3)

**simulation1** (mean-f)

**simulation2** (ABO)

*Summary of one-locus fitness models.Types of selection in nature.Fitness coefficients.Cyclical environment.Interaction between species.*

**lecture 4** (lecture4)

**simulation1** (mnuopt1)

**simulation2** (mnuopt2)

**simulation4** (mnuopt3)

*Fertility selection.Frequency depended selection.Deterministic chaos.*

**lecture 5** (lecture5)

**simulation1** (fertil-cicle)

**simulation2** (chaos-freq)

**simulation3** (feigenbaum)

**simulation4** (fractal)

*Finite population.*

**lecture 6** (lecture6)

**simulation1** (determ-chaos-distributions)

**simulation2** (finite-traject)

*Free populations: Two-locus systems, recombination, measure of disequilibria, equlibrium points. Multilocus multiallele population,linkage distribution,polyploids systems.*

**lecture 7** (lecture7)

**simulation1** (free-pop)

*Two-locus selection-make the first move.One-locus selection and one locus free population from two-locus system with one selected and one neutral locus.Genetic Hitchhiking. One-locus selection from two-locus selection.Epistatic selection.*

**lecture 8** (lecture8)